IM Acute exposure to blood containing HBsAg 0.06 mL/kg as soon as possible after exposure & w/in 24 hrs if possible. If hepatitis B vaccine is refused, give 2nd dose of hepatitis B Ig (human) 1 mth after 1st dose.
Prophylaxis of infant born to HBsAg & HBeAg mothers 0.5 mL after physiologic stabilization of the infant & preferably w/in 12 hr after birth. Administer hepatitis B vaccine in 3 doses of 0.5 mL each. Give the 1st dose w/in 7 days of birth & may be given concurrently w/ hepatitis B Ig (human) but at a separate site. Give 2nd & 3rd doses of vaccine 1 & 6 mth respectively after the 1st. If administration of the 1st dose of hepatitis B vaccine is delayed for as long as 3 mth, a 0.5 mL dose of hepatitis B Ig (human) should be repeated after 3 mth. If hepatitis B vaccine is refused, the 0.5 mL dose of hepatitis B Ig (human) should be repeated at 3 & 6 mth.
Sexual exposure to an HBsAg +ve person 0.06 mL/kg single dose & should begin the hepatitis B vaccine series if prophylaxis can be started w/in 14 days of the last sexual contact or if sexual contact w/ the infected person will continue.
Household exposure to person w/ acute HBV infection Infant <12 mth 0.5 mL w/ hepatitis B vaccine. May be administered at the same time (at different site) or up to 1 mth preceding hepatitis B vaccination w/o impairing the active immune response from hepatitis B vaccination.
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